Athletes with SRC who performed one 20-minute bout of moderate aerobic exercise showed improved executive function without worsening symptoms. The benefit persisted 24 hours later, suggesting that even short, controlled exercise may support recovery.

Computational analysis identified candidate genes such as APOE, GFAP, and UCHL1 as well as miRNAs like hsa-miR-10a-5p that may influence the severity and recovery of mTBI. These findings highlight potential targets for future diagnostic tools.

A meta-analysis of nine randomized controlled trials involving 346 participants found that early initiation of high-to-moderate intensity aerobic exercise reduced concussion symptoms compared to strict rest. This supports replacing prolonged rest with safe, guided movement.